Estriol Face Cream
Topical Cream · Estriol 0.3%
- Supports firmness and hydration
- Addresses post-menopausal skin change
- Simple nightly application
Choose your plan
Why Estriol for skin?
Skin loses collagen quickly in the years around menopause, which is why texture and hydration change so noticeably then. Estriol is a weak oestrogen applied topically to support the skin locally. Absorption into the bloodstream is low, but it remains a hormone, so your history is reviewed before prescribing.
What to expect
- Nightly application — To clean, dry skin as part of an evening routine.
- Addresses a specific cause — The collagen loss that follows falling oestrogen.
- Weeks for hydration — Firmness and texture take several months.
- It is still a hormone — Your history is reviewed before prescribing.
How it works
Online consultation
Answer a few health questions — a licensed provider reviews online. No waiting rooms.
Prescription approved
Once approved, your medication ships discreetly to your door.
Feel the difference
Physician-guided support and check-ins keep results on track.
Dosing, safety & what's inside
Apply a small amount to a clean, dry face at night; use nightly unless directed otherwise
There is no FDA approved estriol product in the United States, so there is no FDA reviewed safety label for this cream and no established side effect rate. Estriol is an estrogen. Estrogen products carry serious warnings when taken systemically, and how much of a topical facial cream reaches the bloodstream has not been established.
Tell your care team straight away if you get unusual vaginal bleeding, breast tenderness or a new lump, or swelling or a rash where you applied it.
This is not a complete list of side effects. Message your care team about any symptom that worries you. What we dispense is a compounded preparation made by a licensed US pharmacy. Compounded medications are not approved by the FDA for safety, efficacy or quality.
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Common questions
How is this different from a retinoid?
A retinoid works on cell turnover. Estriol addresses the specific loss of collagen and hydration that follows falling oestrogen. They target different causes and are sometimes used together.
Is it absorbed into my body?
Absorption is low at the concentrations used, but not zero. That is why your history is reviewed first.
How long before I see a change?
Hydration often improves within weeks. Firmness and texture take several months of consistent use.
Who should not use it?
It is not for use in pregnancy, and anyone with a history of hormone-sensitive cancer should discuss it with their clinician before starting.
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Built by a health team that's actually on your side
Prof Brian Kennedy, PhD
Globally recognized aging biologist and former CEO of the Buck Institute for Research on Aging, renowned for pioneering research on sirtuins, mTOR, and healthy aging.
Matt Kaeberlein
World-leading biogerontologist and Founding Director of the Healthy Aging & Longevity Research Institute, celebrated for uncovering the biological mechanisms of aging.
Rhonda Collins, FNP-C
Board-certified Family Nurse Practitioner with 15+ years of clinical experience, specializing in preventative wellness and biomarker-driven personalized care.