Estradiol Oral
Tablet · 1 mg (0.5-2 mg range)
- Relieves hot flashes & sleep issues
- Simple daily tablet
- Supports mood & bone health
Choose your plan
How does oral estradiol work?
Bioidentical estradiol taken by mouth to address hot flashes, sleep changes, mood, and long-term bone protection. Titrated to your symptoms and labs. Progesterone is co-prescribed for uterine protection when indicated.
What to expect
- Bloodwork first — Baseline labs and history determine whether therapy is appropriate.
- One tablet daily — The simplest routine of the estrogen options.
- Route matters — Your clinician will explain why oral may or may not suit your risk profile.
- Two to four weeks — Vasomotor symptoms are usually the first to improve.
How it works
Online consultation
Answer a few health questions — a licensed provider reviews online. No waiting rooms.
Prescription approved
Once approved, your medication ships discreetly to your door.
Feel the difference
Physician-guided support and check-ins keep results on track.
Dosing, safety & what's inside
Take 1 tablet by mouth daily; titrate per symptoms and follow-up labs; co-prescribe progesterone for uterine protection where indicated
Estrogen raises the risk of cancer of the uterus lining. Estrogen with a progestin should not be used to prevent heart disease or dementia. In the Women's Health Initiative, estrogen with a progestin raised the risk of heart attack, stroke, invasive breast cancer, and blood clots in the lungs and legs.
Tell your care team straight away if you get any unusual vaginal bleeding, chest pain or shortness of breath, pain or swelling in a leg, sudden vision loss or change, a sudden severe headache or weakness on one side, yellowing of your skin or eyes, or swelling of your face, lips or throat.
Common side effects
- nausea and vomiting
- breast tenderness or enlargement
- headache
- abdominal cramps
- changes in vaginal bleeding
- dizziness
- low mood
- hair loss
- darkening of the skin
Rare but serious
- cancer of the uterus lining
- breast cancer
- ovarian cancer
- stroke and heart attack
- blood clots in the legs or lungs
- gallbladder disease needing surgery
- probable dementia in women aged 65 and over
Do not take this if you have unexplained vaginal bleeding, you have or have had breast cancer or another estrogen-dependent cancer, you have had a blood clot in a leg or lung, you have had a stroke or heart attack, you have liver disease, or you are or may be pregnant.
This is not a complete list of side effects. Message your care team about any symptom that worries you.
More in this category
Advanced Panel
Comprehensive panel across 12 body systems.
Essential Panel
Core biomarker panel — the fastest way to start treatment.
BiEst 80/20 Hormone Cream
Topical Cream · 2.5 mg/mL (80% estriol / 20% estradiol)
Enclomiphene
Capsule · 12.5 mg / 25 mg
Estradiol Oral
Tablet · 1 mg (0.5-2 mg range)
Progesterone Capsules
Capsule · 100 mg / 200 mg
Semaglutide + B12
Injection · 2.5 mg/mL (semaglutide)
Sildenafil
Tablet · 100 mg
Tadalafil Daily
Tablet · 5 mg
Tirzepatide + B12
Injection · 10 mg/mL (tirzepatide)
Anastrozole Add-On
Tablet · 0.25 mg
Cedar Hair Tablet | Finasteride + Minoxidil + Biotin
Tablet · 1 mg / 2.5 mg / biotin
Levothyroxine
Tablet · 50 mcg (25-100 mcg range)
Liothyronine
Tablet · 5 mcg
NAD+ Injection
Injection · 200 mg/mL
Progesterone Cream
Topical Cream · 20 mg/mL
Clomiphene
Capsule · 25 mg
DHEA Vaginal Suppository
Vaginal Suppository · 6.5 mg
Estradiol Vaginal Cream
Vaginal Cream · 0.1%
Estriol Face Cream
Topical Cream · Estriol 0.3%
Euphoria O | Oxytocin + L-Arginine Cream
Topical Cream · 30 mg/50 IU per g
Finasteride + Minoxidil Scalp Solution
Topical Solution · 0.1% / 10%
Liraglutide Injection
Injection · 6 mg/mL
Low-Dose Naltrexone (LDN)
Capsule · Flex-dose (1.5 to 4.5 mg)
MIC + B12 Injection
Injection · MIC + B12 1000 mcg
MICC Lipotropic Injection
Injection · Methionine / Inositol / Choline / B12
Rosacea Triple Cream
Topical Cream · Triple combination
Sermorelin Injection
Injection · 1 mg/mL
Sildenafil Arousal Cream
Topical Cream · 4%
Vitamin B12 Injection
Injection · 5 mg/mL methylcobalamin
Common questions
How does oral estradiol differ from transdermal?
Taken by mouth, estradiol passes through the liver first. That is associated with a higher risk of blood clots than transdermal routes, which is why patches and gels are often preferred. Oral remains appropriate for many people and is simple to take.
When do I take it?
Once daily, at roughly the same time. It can be taken with or without food.
How soon will symptoms improve?
Hot flushes and night sweats commonly ease within two to four weeks, with sleep and mood following.
Do I need progesterone alongside estrogen?
If you still have a uterus, yes — unopposed estrogen increases the risk of endometrial changes. Your clinician will prescribe progesterone alongside as standard.
What are the risks I should know about?
Menopausal hormone therapy carries risks that depend on your age, time since menopause, personal and family history, and the route of delivery. Your clinician goes through these with you before prescribing. It is not appropriate for everyone.
Start your plan today
Built by a health team that's actually on your side
Prof Brian Kennedy, PhD
Globally recognized aging biologist and former CEO of the Buck Institute for Research on Aging, renowned for pioneering research on sirtuins, mTOR, and healthy aging.
Matt Kaeberlein
World-leading biogerontologist and Founding Director of the Healthy Aging & Longevity Research Institute, celebrated for uncovering the biological mechanisms of aging.
Rhonda Collins, FNP-C
Board-certified Family Nurse Practitioner with 15+ years of clinical experience, specializing in preventative wellness and biomarker-driven personalized care.