Estradiol Oral Capsule
Capsule · 1.1 mg
- Relieves hot flashes & sleep issues
- Simple daily capsule
- Supports mood & bone health
Choose your plan
How does oral estradiol work?
Bioidentical estradiol taken by mouth to address hot flashes, sleep changes, mood, and long-term bone protection. Titrated to your symptoms and labs. Progesterone is co-prescribed for uterine protection when indicated.
What to expect
- Bloodwork first — Baseline labs and history determine whether therapy is appropriate.
- One capsule daily — The simplest routine of the estrogen options.
- Route matters — Your clinician will explain why oral may or may not suit your risk profile.
- Two to four weeks — Vasomotor symptoms are usually the first to improve.
How it works
Online visit and review
Answer a few health questions. A licensed clinician reviews them online. No waiting rooms.
Ships to your door
If prescribed, your medication ships free and discreetly.
Feel the difference
Your clinician checks in and adjusts your plan as you go.
Dosing, safety & what's inside
Take 1 capsule by mouth daily; titrate per symptoms and follow-up labs; co-prescribe progesterone for uterine protection where indicated
Estrogen raises the risk of cancer of the uterus lining. Estrogen with a progestin should not be used to prevent heart disease or dementia. In the Women's Health Initiative, estrogen with a progestin raised the risk of heart attack, stroke, invasive breast cancer, and blood clots in the lungs and legs.
Tell your care team straight away if you get any unusual vaginal bleeding, chest pain or shortness of breath, pain or swelling in a leg, sudden vision loss or change, a sudden severe headache or weakness on one side, yellowing of your skin or eyes, or swelling of your face, lips or throat.
Common side effects
- nausea and vomiting
- breast tenderness or enlargement
- headache
- abdominal cramps
- changes in vaginal bleeding
- dizziness
- low mood
- hair loss
- darkening of the skin
Rare but serious
- cancer of the uterus lining
- breast cancer
- ovarian cancer
- stroke and heart attack
- blood clots in the legs or lungs
- gallbladder disease needing surgery
- probable dementia in women aged 65 and over
Do not take this if you have unexplained vaginal bleeding, you have or have had breast cancer or another estrogen-dependent cancer, you have had a blood clot in a leg or lung, you have had a stroke or heart attack, you have liver disease, or you are or may be pregnant.
This is not a complete list of side effects. Message your care team about any symptom that worries you.
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Common questions
How does oral estradiol differ from transdermal?
Taken by mouth, estradiol passes through the liver first. That is associated with a higher risk of blood clots than transdermal routes, which is why patches and gels are often preferred. Oral remains appropriate for many people and is simple to take.
When do I take it?
Once daily, at roughly the same time. It can be taken with or without food.
How soon will symptoms improve?
Hot flushes and night sweats commonly ease within two to four weeks, with sleep and mood following.
Do I need progesterone alongside estrogen?
If you still have a uterus, yes — unopposed estrogen increases the risk of endometrial changes. Your clinician will prescribe progesterone alongside as standard.
What are the risks I should know about?
Menopausal hormone therapy carries risks that depend on your age, time since menopause, personal and family history, and the route of delivery. Your clinician goes through these with you before prescribing. It is not appropriate for everyone.
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Board-certified Family Nurse Practitioner with 15+ years of clinical experience, specializing in preventative wellness and biomarker-driven personalized care.