
Tablet · 25 mg

At the low doses used for weight, topiramate reduces appetite and the pull of cravings. It is prescribed off-label and titrated slowly, because most of its side effects rise with dose. Because it carries a known pregnancy risk, contraception is part of the conversation before you start.


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Take 1 tablet by mouth daily, increasing gradually as directed by your clinician
Topiramate is FDA approved for epilepsy and migraine prevention. Using it for weight is off-label, which means the FDA has not reviewed it for this use. The side effect rates below come from epilepsy trials.
Tell your care team straight away if your vision blurs suddenly or your eye hurts, you get new or worse thoughts of suicide, you stop sweating or overheat, you breathe fast or feel very tired or lose your appetite, you get a rash with blistering or peeling, or you get severe back or side pain when passing urine.
Common side effects
Rare but serious
Do not take this if you have reacted badly to topiramate before.
This is not a complete list of side effects. Message your care team about any symptom that worries you.
Topiramate is approved for epilepsy and migraine. Use for weight is off-label and at much lower doses, based on its well-documented effect on appetite.
A pins-and-needles sensation in the hands and feet is the most commonly reported effect. It is usually mild and often settles, but tell your clinician if it does not.
For some people, yes — carbonated drinks in particular can taste flat or metallic. It is harmless and reverses on stopping.
No. Topiramate carries a known risk of birth defects. Effective contraception is required throughout treatment, and this is confirmed before prescribing.

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