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Lose Weight

Semaglutide + B12

Injection · 2.5 mg/mL (semaglutide)

  • Effective weekly GLP-1 therapy
  • B12 to support daily energy
  • Cost-friendly compounded option
★★★★★
4.9 · 1,200+ member reviews

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1-month
Billed monthly
$
249
/mo
249
3-month
Billed quarterly
$
229
/mo
249
Billed twice a year
$
199
/mo
249
Billed annually
$
179
/mo
249
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Semaglutide + B12
care-semaglutide
Cancel anytime · Free shipping · Prescribed only if appropriate
US-licensed clinicians
Ships from US pharmacies
HSA/FSA eligible

What is Semaglutide?

A GLP-1 agonist that quiets food noise, regulates appetite, and supports gradual, sustained weight loss when paired with lifestyle changes. Our compounded formulation adds B12 to reduce nausea and glycine to help preserve lean muscle. Titrated slowly to the lowest effective dose.

What to expect

What to expect

  • A starting dose that steps up — Treatment begins low and increases gradually so your body adjusts and side effects stay manageable.
  • Appetite changes first — Most people notice reduced appetite and earlier fullness before they notice the scale moving.
  • Steady, not sudden — A healthy pace is roughly one to two pounds a week. Faster is not better.
  • Nausea is common early — It usually settles within a few weeks and eases with smaller, slower meals.

How it works

Online consultation with a licensed clinician
Step 1

Online consultation

Answer a few health questions — a licensed provider reviews online. No waiting rooms.

A few minutes
Prescription approved
Step 2

Prescription approved

Once approved, your medication ships discreetly to your door.

Within 72 hours
Feeling the differenceFeeling the difference
Step 3

Feel the difference

Physician-guided support and check-ins keep results on track.

2–5 business days

Dosing, safety & what's inside

How to dose

Month 1: 0.2 mg SC once weekly Month 2: 0.4 mg SC once weekly Month 3: 0.9 mg SC once weekly Titrate to lowest effective dose; hold dose if significant GI side effects

Risks & side effects

Semaglutide caused thyroid C-cell tumors in rodents. Whether that happens in people is not known.

Tell your care team straight away if you feel a lump or swelling in your neck, your voice goes hoarse or swallowing becomes hard, you get severe stomach pain that will not stop, you cannot keep fluids down, you get pain in your upper right belly or your eyes turn yellow, or your face, lips or tongue swell.

Common side effects

  • nausea
  • diarrhea
  • vomiting
  • constipation
  • abdominal pain
  • headache
  • fatigue
  • dizziness
  • hair loss

Rare but serious

  • acute pancreatitis
  • gallbladder disease and gallstones
  • kidney injury from fluid loss
  • low blood sugar
  • worsening diabetic eye disease
  • food left in the stomach during anesthesia

Do not take this if you or a family member has had medullary thyroid carcinoma, you have Multiple Endocrine Neoplasia syndrome type 2, or you have reacted badly to semaglutide before.

This is not a complete list of side effects. Message your care team about any symptom that worries you. What we dispense is a compounded preparation made by a licensed US pharmacy. Compounded medications are not approved by the FDA for safety, efficacy or quality.

Common questions

How does semaglutide work?

It mimics GLP-1, a hormone your gut releases after eating. That slows stomach emptying and signals fullness to the brain, so you eat less without white-knuckling it. This formulation also includes glycine and B12.

How often do I inject?

Once weekly, as a small subcutaneous injection you do at home on the same day each week. Your care team walks you through technique.

How quickly will I lose weight?

Most people see steady loss over months rather than weeks, and the first few weeks are usually about tolerating the dose rather than results. Expect appetite changes before scale changes.

What are the common side effects?

Nausea, constipation, diarrhoea and reflux are the most common, and are usually worst in the days after a dose increase. Eating smaller portions more slowly helps. Tell your clinician about anything severe or persistent.

What happens if I stop?

Appetite generally returns and weight regain is common without other changes in place. This is why the habits you build during treatment matter as much as the medication.

Who should not take this?

It is not appropriate if you have a personal or family history of medullary thyroid carcinoma or MEN 2, and it is not for use in pregnancy. Your intake covers the full list of contraindications.

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1-month
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/mo
Billed monthly
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1mo
Semaglutide + B12
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3-month
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Billed quarterly
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3mo
Semaglutide + B12
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6-month
$
179
/mo
Billed twice a year
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6mo
179
Semaglutide + B12
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Built by a health team that's actually on your side

Prof Brian Kennedy, PhD

Prof Brian Kennedy, PhD

Scientific Advisor

Globally recognized aging biologist and former CEO of the Buck Institute for Research on Aging, renowned for pioneering research on sirtuins, mTOR, and healthy aging.

Matt Kaeberlein

Matt Kaeberlein

Scientific Advisor

World-leading biogerontologist and Founding Director of the Healthy Aging & Longevity Research Institute, celebrated for uncovering the biological mechanisms of aging.

Rhonda Collins, FNP-C

Rhonda Collins, FNP-C

Care Team Lead

Board-certified Family Nurse Practitioner with 15+ years of clinical experience, specializing in preventative wellness and biomarker-driven personalized care.