Methylene Blue
Capsule · 5 mg
- Supports mitochondrial function
- Low daily dose
- Used in longevity protocols
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What is Methylene Blue?
At low doses methylene blue can act as an electron carrier in mitochondria, which is why it appears in longevity protocols aimed at energy metabolism and cognition. The important caveat is not the evidence but the interactions — it behaves as an MAO inhibitor, which rules it out alongside several common antidepressants.
What to expect
- Blue urine is expected — Harmless, and not a reason to stop.
- Medication review first — The interaction list is the main constraint.
- Early evidence — Interesting mechanism, limited human data.
- One low daily dose — Far below doses used clinically for other purposes.
How it works
Online consultation
Answer a few health questions — a licensed provider reviews online. No waiting rooms.
Prescription approved
Once approved, your medication ships discreetly to your door.
Feel the difference
Physician-guided support and check-ins keep results on track.
Dosing, safety & what's inside
Take 1 capsule by mouth daily, or as directed by your clinician
Methylene blue can cause serotonin syndrome when taken with antidepressants and some other medicines. Tell your care team every medication and supplement you take.
Methylene blue is FDA approved as an intravenous treatment for methemoglobinemia, a blood disorder. Using it for focus, energy or aging is off-label, which means the FDA has not reviewed it for those uses.
Tell your care team straight away if you get agitation, confusion, shivering, muscle twitching or fever, especially if you take an antidepressant. Also tell us if your urine goes dark or your skin yellows, you feel unusually weak or look pale, you have a seizure, or you get a severe rash or trouble breathing.
Common side effects
- headache
- low potassium
- diarrhea
- low magnesium
- muscle jerking
- nausea
Rare but serious
- serotonin syndrome
- breakdown of red blood cells, which can be delayed
- serious harm if you have G6PD deficiency
- harm to a pregnancy
- falsely low oxygen readings on a finger monitor
Do not take this if you have G6PD deficiency, or you have reacted badly to methylene blue or thiazine dyes before.
This is not a complete list of side effects. Message your care team about any symptom that worries you. What we dispense is a compounded preparation made by a licensed US pharmacy. Compounded medications are not approved by the FDA for safety, efficacy or quality.
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Common questions
Why does it turn urine blue?
Because the compound itself is a dye. Blue or green urine is expected, harmless, and not a reason to stop.
What is the interaction risk?
Methylene blue acts as a monoamine oxidase inhibitor. Combined with SSRIs, SNRIs and other serotonergic medications it can cause serotonin syndrome, which is serious. A full medication review comes before any prescription.
What is the evidence?
Mechanistic work is interesting and clinical use at higher doses is long established for other purposes. Evidence for cognitive or longevity benefit in healthy adults is early.
Who should not take it?
Anyone on serotonergic medication, anyone with G6PD deficiency, and anyone pregnant.
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Built by a health team that's actually on your side
Prof Brian Kennedy, PhD
Globally recognized aging biologist and former CEO of the Buck Institute for Research on Aging, renowned for pioneering research on sirtuins, mTOR, and healthy aging.
Matt Kaeberlein
World-leading biogerontologist and Founding Director of the Healthy Aging & Longevity Research Institute, celebrated for uncovering the biological mechanisms of aging.
Rhonda Collins, FNP-C
Board-certified Family Nurse Practitioner with 15+ years of clinical experience, specializing in preventative wellness and biomarker-driven personalized care.