Liothyronine
Tablet · 5 mcg
- Active (T3) thyroid hormone
- Targets stubborn symptoms
- Clinician-titrated dosing
Choose your plan
This treatment starts with labs
Your clinician needs recent blood work to prescribe safely. Two ways to get it done:
What is Liothyronine (T3)?
T3 augmentation for members with persistent thyroid symptoms and low Free T3 despite adequate T4 levels. Prescribed when labs confirm conversion issues. Requires lab monitoring before every refill.
What to expect
- Usually an addition — T3 is added to T4 therapy rather than replacing it.
- Split dosing — Short-acting, so often taken twice daily on a set schedule.
- Watch for overshoot — Palpitations, tremor or poor sleep can signal too high a dose.
- Timed bloodwork — When you draw blood relative to your dose affects the result.
From order to optimized
Health assessment panel
Quick lab panel at 2,000+ locations near you — or upload recent bloodwork and we may use your existing results.
Review your results
A licensed clinician reviews your levels, symptoms and goals, builds your personalized plan, and ships it to your door.
Feel the difference
Most members notice improvements within weeks. We recheck labs at 90 days and fine-tune your dose.
How it works
Online consultation
Answer a few health questions — a licensed provider reviews online. No waiting rooms.
Prescription approved
Once approved, your medication ships discreetly to your door.
Feel the difference
Physician-guided support and check-ins keep results on track.
Dosing, safety & what's inside
Take 1 tablet (5 mcg) by mouth daily; may titrate to 5 mcg twice daily based on follow-up labs
Thyroid hormone must not be used for weight loss. Doses larger than your body needs can be dangerous, especially alongside other weight loss medication.
Tell your care team straight away if you get chest pain, a pounding or racing or irregular heartbeat, shortness of breath, tremor or sweating or feeling overheated, or you lose weight without meaning to and cannot sleep.
Common side effects
- palpitations
- a fast heart rate
- tremor
- muscle weakness
- headache
- nervousness
- insomnia
- diarrhea
- feeling too warm
Rare but serious
- heart rhythm problems, particularly if you are older or have heart disease
- worsening angina or heart attack
- adrenal crisis if adrenal insufficiency has not been corrected first
- loss of bone mineral density with long term over-replacement
- loss of blood sugar control if you have diabetes
Do not take this if you have adrenal insufficiency that has not been treated first.
This is not a complete list of side effects. Message your care team about any symptom that worries you.
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Common questions
When is T3 added?
Usually when symptoms persist despite T4 therapy and free T3 remains low. It is not a first-line replacement — T4 is.
How is it dosed?
T3 is short-acting, so it is often split into two smaller doses across the day rather than taken once. Your clinician will set the schedule.
What should I watch for?
Signs of too much: a racing or irregular heartbeat, tremor, anxiety, difficulty sleeping and heat intolerance. Report these rather than adjusting the dose yourself.
How is it monitored?
Through free T3 alongside TSH and free T4. Because T3 is short-acting, timing of your blood draw relative to your dose matters — follow the instruction you are given.
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Board-certified Family Nurse Practitioner with 15+ years of clinical experience, specializing in preventative wellness and biomarker-driven personalized care.