
Injection · 5 mg/mL methylcobalamin

B12 absorption depends on a specific mechanism in the gut that ageing, gut conditions and long-term metformin all interfere with. Injecting bypasses that entirely. It is worth being clear about what it does and does not do: correcting a genuine deficiency helps, but B12 is not a general energy treatment for people whose levels are already normal.


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Inject the prescribed dose subcutaneously or intramuscularly once weekly, or as directed
Vitamin B12 injection is FDA approved for B12 deficiency caused by poor absorption, including pernicious anemia. Using it for energy or weight is off-label.
Tell your care team straight away if you get trouble breathing, throat swelling or hives after an injection, vision changes, chest tightness or leg swelling, muscle weakness, or an irregular heartbeat.
Common side effects
Rare but serious
Do not take this if you are sensitive to cobalt or to vitamin B12.
This is not a complete list of side effects. Message your care team about any symptom that worries you.
People with genuinely low levels — often from age-related absorption changes, gut conditions, a plant-based diet, or long-term metformin use. If your levels are normal, more B12 is unlikely to change how you feel.
B12 is a deep red compound and the excess is excreted. Pink urine for a day or so is expected and harmless.
Typically weekly, though your clinician may set a different schedule. One 10 mL vial covers roughly ten weeks.
B12 is water-soluble and the excess is excreted rather than stored, so toxicity is not a practical concern.

Globally recognized aging biologist and former CEO of the Buck Institute for Research on Aging, renowned for pioneering research on sirtuins, mTOR, and healthy aging.

World-leading biogerontologist and Founding Director of the Healthy Aging & Longevity Research Institute, celebrated for uncovering the biological mechanisms of aging.

Board-certified Family Nurse Practitioner with 15+ years of clinical experience, specializing in preventative wellness and biomarker-driven personalized care.